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SCC310 3dGRO™ Colon Intestinal Organoids, Age 46 (14-881-CR)

Cryopreserved patient derived gastrointestinal organoids (PDOs)

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SCC310
≥1500 viable organoids/vial  
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      Übersicht

      Replacement Information
      Description
      Catalogue NumberSCC310
      Description3dGRO™ Colon Intestinal Organoids, Age 46 (14-881-CR)
      Alternate Names
      • Gut Organoids
      • Human PDO Biobank
      Background InformationPatient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology, thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5+ stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture, presenting more mature phenotypes compared to iPSC-derived organoids. Importantly, PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.

      We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids from both normal and diseased patients derived from multiple regions of the digestive systems including small intestine (duodenum, ileum), stomach, rectum and colon.

      Cell Line Characteristics
      • Sex: Male
      • Age: 46 Years
      • Organ: Colon (Rectum)
      • Disease: Adenocarcinoma (TP53 Pro151Ser, KRAS Gly12Asp, APC Pro1443fs)
      References
      Product Information
      Applications
      ApplicationCryopreserved patient derived gastrointestinal organoids (PDOs)
      Key Applications
      • Stem Cell Culture
      Application Notes3dGRO™ is a trademark of Merck KGaA, Darmstadt, Germany.
      3dGRO™ organoids were derived utilizing HUB Organoid Technology.
      The purchaser of this product shall agree to HUB’s terms of use, which shall be separately acknowledged and accepted by such purchaser, prior to transfer of this product to purchaser.
      Biological Information
      Cell Line Type
      • Organoid
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Viability: ≥1500 viable organoids/vial
      • Organoid Growth: Pass
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Mycoplasma Contamination: Negative
      • STR Profile: Pass
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The organoids can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1500 viable organoids/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      SCC310 04061842199105

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