Millipore Sigma Vibrant Logo

251010 1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
147-94-4C₉H₁₃N₃O₅

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
251010-1GM
Verfügbarkeit wird abgerufen...
Eingeschränkte Verfügbarkeit
Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      Kst.-Ampulle 1 gm
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      Bitte erfragen
      Description
      OverviewAnticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest.
      Catalogue Number251010
      Brand Family Calbiochem®
      SynonymsAra-C, Cytarabine, Cytosine Arabinoside
      References
      ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
      Product Information
      CAS number147-94-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉H₁₃N₃O₅
      Chemical formulaC₉H₁₃N₃O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAnticancer, antiviral agent that is especially effective against leukemias
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSHA5425000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-43-61

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      May cause harm to the unborn child.
      S PhraseS: 22-36-45

      Do not breathe dust.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      251010-1GM 04055977199192

      Documentation

      1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      251010

      Literatur

      Übersicht
      Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2019 JSW
      SynonymsAra-C, Cytarabine, Cytosine Arabinoside
      DescriptionCytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. AraCTP, formed by intracellular phosphorylation of AraC, is utilized as a substrate by DNA polymerases, which incorporate AraCMP residues into DNA. Incorporated 3'-terminal AraCMP residues inhibit further DNA synthesis by impeding chain elongation by DNA polymerase. AraC is used clinically in the treatment of various cancers, particularly leukemias and lymphomas. Also used to inhibit proliferation of cultured cells and replication of eukaryotic viruses (e.g. vaccinia virus, herpes simplex virus). Also shown to induce apoptosis in human myeloid leukemia cells and in post-mitotic rat sympathetic neurons.
      FormWhite solid
      CAS number147-94-4
      RTECSHA5425000
      Chemical formulaC₉H₁₃N₃O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (1 mM)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 2784
      ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.