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565772 γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem

The γ-Secretase Inhibitor XI, also referenced under CAS 62252-26-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 7-Amino-4-chloro-3-methoxyisocoumarin, JLK6

Primary Target: γ-secretase and blocks the production of both Aβ₄₀ and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      62252-26-0C₁₀H₈ClNO₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, active site directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 (IC50 < 100 µM) in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP).
      Note: t1/2 = 200 min in 100 µM HEPES, 500 µM NaCl, and 10% DMSO, pH 7.5.
      Catalogue Number565772
      Brand Family Calbiochem®
      Synonyms7-Amino-4-chloro-3-methoxyisocoumarin, JLK6
      References
      ReferencesEsler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
      Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
      Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
      Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
      Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.
      Product Information
      CAS number62252-26-0
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₀H₈ClNO₃
      Chemical formulaC₁₀H₈ClNO₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetγ-secretase and blocks the production of both Aβ₄₀ and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
      Primary Target IC<sub>50</sub>< 100 µM against γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. This product is not stable in aqueous solution, hence, dilute in aqueous solution right prior to use (t½ at 25°C = 3.3 h in 100 mM HEPES, 500 mM NaCl, pH 7.5, with 10% DMSO).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      565772 0

      Documentation

      γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      565772

      Literatur

      Übersicht
      Esler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
      Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
      Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
      Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
      Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms7-Amino-4-chloro-3-methoxyisocoumarin, JLK6
      DescriptionA non-peptidic, cell-permeable, active site-directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β 40 (Aβ40) and 42 (Aβ42) in HEK293 cells (70-80% inhibition at 100 µM concentration) expressing wild-type and Swedish-mutant β-amyloid precursor protein (βAPP). Does not exhibit any significant effect on either the processing or mΔEnotch-1 or the endoproteolysis of presenilins.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number62252-26-0
      Chemical formulaC₁₀H₈ClNO₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. This product is not stable in aqueous solution, hence, dilute in aqueous solution right prior to use (t½ at 25°C = 3.3 h in 100 mM HEPES, 500 mM NaCl, pH 7.5, with 10% DMSO).
      Toxicity Standard Handling
      ReferencesEsler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
      Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
      Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
      Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
      Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.