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537075 (±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl

Primary Target: β1 and β2 adrenergic receptors
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      3506-09-0C₁₆H₂₁NO₂ · HCl
      Description
      OverviewA highly lipophilic agent that blocks both β1 and β2 adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.
      Catalogue Number537075
      Brand Family Calbiochem®
      Synonyms(±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
      References
      ReferencesFujita, K., et al. 1996. FEBS Lett. 395, 293.
      Glennon, R.A., et al. 1996. Mol. Pharmacol. 49, 198.
      Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12, 404.
      Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.
      Product Information
      CAS number3506-09-0
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₁₆H₂₁NO₂ · HCl
      Chemical formulaC₁₆H₂₁NO₂ · HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetβ1 and β2 adrenergic receptors
      Primary Target K<sub>i</sub>17 nM for 5HT-1B receptors
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUB7526000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      537075 0

      Documentation

      (±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      (±)-Propranolol, Hydrochloride - CAS 3506-09-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      537075

      Literatur

      Übersicht
      Fujita, K., et al. 1996. FEBS Lett. 395, 293.
      Glennon, R.A., et al. 1996. Mol. Pharmacol. 49, 198.
      Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12, 404.
      Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-August-2017 JSW
      Synonyms(±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl
      DescriptionA highly lipophilic β-adrenergic blocker. Blocks both β1 and β2 receptors with equal potency. Has no effect on a-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D or phospholipase C mediated DAG production. An antihypertensive agent that is also used in the treatment of cardiac arrhythmias.
      FormWhite powder
      CAS number3506-09-0
      RTECSUB7526000
      Chemical formulaC₁₆H₂₁NO₂ · HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityMethanol or H₂O
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Harmful
      Merck USA index14, 7840
      ReferencesFujita, K., et al. 1996. FEBS Lett. 395, 293.
      Glennon, R.A., et al. 1996. Mol. Pharmacol. 49, 198.
      Thompson, N.T., et al. 1991. Trends Pharmacol. Sci. 12, 404.
      Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.