HPDE6c7 Human Pancreatic Duct Epithelial Cell Line

Pancreatic cancer is the fourth commonest cause of cancer death in North America and has one of the worst prognoses. Greater than 90% of these tumors arise from the pancreatic duct epithelium.1 Even when the primary tumor is small and localized, the prognosis remains poor and chemotherapy or radiotherapy has demonstrated limited effectiveness.2 The availability of dynamic models remains crucial to the study and understanding of the biological significance of the genetic changes underlying pancreatic cancer, especially in the context of pancreatic duct epithelial cell carcinogenesis.
The immortalized HPDE6c7 cell line demonstrates a near normal genotype and phenotype of pancreatic duct epithelial cells.3 HPDE6c7 cells retain normal Ki-ras, p53, C-myc, and p16INK4A genotypes but lack the p53 functional pathway.3 The HPDE6c7 cell line is useful for studies on the molecular basis of pancreatic duct cell carcinogenesis and islet cell differentiation. HPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.

Source
HPDE6c7 cells originated from normal human pancreatic duct of a 63-year-old female, having been genotypically altered by infection with retrovirus vector expressing E6E7 genes of human papilloma virus (HPV)-16.3


References
1. Am J Pathol 1996, 148(6): 1763-1770.
2. Am J Pathol 1998, 153(1): 263-269.
3. Am J Pathol 2000, 157(5): 1623-1631.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

HPDE6c7 cells are a versatile model for the pancreatic ductal epithelium, facilitating the development of strategies for the chemoprevention of human pancreatic cancers.

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.