681629
W-7, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM).
동의어(들):
W-7, Hydrochloride, N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C16H21ClN2O2S · xHCl
CAS 번호:
Molecular Weight:
340.87 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
crystalline solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
SMILES string
[S](=O)(=O)(NCCCCCCN)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
InChI
1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChI key
OMMOSRLIFSCDBL-UHFFFAOYSA-N
description
RTECS - QK0786000
assay
≥98% (TLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
off-white
solubility
DMSO: 5 mg/mL, DMF: soluble, warm ethanol: soluble
shipped in
ambient
Quality Level
storage temp.
2-8°C
General description
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Myosin light chain kinase
Myosin light chain kinase
Product does not compete with ATP.
Reversible: yes
Target IC50: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase
Other Notes
Caulfield, M.P., et al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 681629-10MGCN | 04055977260144 |
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