554718
REV-ERBα Antagonist, SR8278
The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
동의어(들):
REV-ERBα Antagonist, SR8278, SR8278SR 8278
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H19NO3S2
CAS 번호:
Molecular Weight:
361.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
제품 이름
REV-ERBα Antagonist, SR8278, The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
InChI key
JRLOEMCOOZSCQP-UHFFFAOYSA-N
SMILES string
n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2
assay
>95% (HPLC)
form
gum
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to yellow-brown
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Disclaimer
Toxicity: Regulatory Review (Z)
General description
A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
Other Notes
Kojetin, D., et al. 2010, Chem Bio in press
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Fang-Yuan Mao et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Rev-erbα was examined in gastric samples from H pylori-infected patients and mice. Gastric epithelial cells (GECs)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 554718-5MGCN | 04055977193114 |
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