5.30618
Pin1 Inhibitor, DTM
동의어(들):
Pin1 Inhibitor, DTM, PPIase-Parvulin Inhibitor II
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H20N2S3
CAS 번호:
Molecular Weight:
288.50
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze
protect from light
protect from light
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Pin1
Pin1
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Other Notes
Yoon, W-J., et al. 2013. J. Cell Physiol.228, 2377.
Tatara, Y., et al. 2009.Biochem Biophys Res Commun.384, 394.
Tatara, Y., et al. 2009.Biochem Biophys Res Commun.384, 394.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 5.30618.0001 | 04055977260984 |
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