5.06416
Retro-inverso TAT-Beclin-1
≥95% (HPLC), Beclin Activator, powder
동의어(들):
Beclin-1 Activator II, retro-inverso TAT-Beclin-1, (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C164H251N57O45
Molecular Weight:
3741.10
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze
desiccated (hygroscopic)
protect from light
desiccated (hygroscopic)
protect from light
제품 이름
Beclin-1 Activator II, retro-inverso TAT-Beclin-1,
color
white
assay
≥95% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
solubility
DMSO: 50 mg/mL
water: 50 mg/mL
storage temp.
2-8°C
Quality Level
관련 카테고리
Biochem/physiol Actions
Cell permeable: yes
Primary Target
GAPR-1/GLIPR2
GAPR-1/GLIPR2
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
Tat-beclin 1, a peptide, is derived from a segment of the autophagy protein beclin 1, which binds to human immunodeficiency virus (HIV)-1 Nef. It serves as a potent inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a recently identified negative regulator of autophagy. Tat-beclin 1 has been found to reduce the accumulation of polyglutamine expansion protein aggregates and the replication of various pathogens (including HIV-1) in vitro. Moreover, it has demonstrated the ability to decrease mortality in mice infected with chikungunya or West Nile virus.
Legal Information
Sold under license of US Patent 8,722,628.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
(D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH
Shoji-Kawata, S., et al. 2013. Nature.494, 201.
Packaging
Packaged under inert gas
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Identification of a candidate therapeutic autophagy-inducing peptide.
Shoji-Kawata S, et al.
Nature, 494(7436), 201-201 (2013)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 5.06416.0001 | 04055977243321 |
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