407616
IL-1R Antagonist
≥95% (HPLC), Interleukin-1 receptor antagonist, oil
동의어(들):
IL-1R Antagonist, BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H26N2O2
CAS 번호:
Molecular Weight:
302.41
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
제품 이름
IL-1R Antagonist, The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R.
SMILES string
N2(CCCC2)C(=O)[C@@H](NC(=O)CCc1ccccc1)C(C)C
InChI
1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,19,21)/t17-/m0/s1
InChI key
DAZSWUUAFHBCGE-KRWDZBQOSA-N
assay
≥95% (HPLC)
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
colorless
solubility
DMSO: 10 mg/mL
ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
Quality Level
관련 카테고리
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TIR domain-mediated MyD88/IL1-RI interaction
TIR domain-mediated MyD88/IL1-RI interaction
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
Other Notes
Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
저장 등급
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Shiqin Xiong et al.
Arteriosclerosis, thrombosis, and vascular biology, 41(11), 2773-2785 (2021-09-10)
[Figure: see text].
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 407616-10MGCN | 04055977211337 |
| 407616-25MGCN | 04055977211344 |
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