400087
HIF-2α Translation Inhibitor
The HIF-2α Translation Inhibitor, also referenced under CAS 882268-69-1, controls the biological activity of HIF-2α. This small molecule/inhibitor is primarily used for Cell Structure applications.
동의어(들):
HIF-2α Translation Inhibitor, Hypoxia-Inducible Factor-2α Translation Inhibitor, Methyl-3-(2-(cyano(methylsulfonyl)methylene)hydrazino)thiophene-2-carboxylate, HIF Inhibitor II
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C9H9N3O4S2
CAS 번호:
Molecular Weight:
287.32
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (sum of two isomers)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
amber
solubility
DMSO: 5 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable thienylhydrazone compound that suppresses the translation of cellular HIF-2α message by enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5′ UTR of the HIF-2α mRNA, exhibiting otherwise no effects toward the transcription of HIF-2α mRNA or the stability of HIF-2α mRNA and protein. Shown to reduce cellular protein levels of HIF-2α and HIF-2α target genes, including Glut-1, IGFBP3, and VEGF, in 786-O cells (5 to 10 µM final concentration) that express only the 2α isoform of hypoxia-inducible factor.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Zimmer, M., et al. 2008. Mol. Cell32, 838.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Mai M Alzaydi et al.
American journal of respiratory cell and molecular biology, 68(1), 103-115 (2022-10-21)
Mitochondrial fission and a metabolic switch from oxidative phosphorylation to glycolysis are key features of vascular pathology in pulmonary arterial hypertension (PAH) and are associated with exuberant endothelial proliferation and apoptosis. The underlying mechanisms are poorly understood. We describe the
Lijiao Zhang et al.
International journal of chronic obstructive pulmonary disease, 17, 2383-2399 (2022-10-04)
Skeletal muscle dysfunction is an important comorbidity in patients with chronic obstructive pulmonary disease (COPD), and is associated with poor quality of life and reduced survival, but the mechanisms involved remain elusive. Ferroptosis is a newly discovered type of cell
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 400087-10MGCN | 04055977212341 |
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