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Merck

390238

Camptothecin

from Camptotheca acuminata, ≥95% (HPLC), powder, DNA topoisomerase I inhibitor, Calbiochem®

동의어(들):

Camptothecin, 10-Hydroxy-, Camptotheca acuminata, 10-Hydroxycamptothecin, HCPT

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C20H16N2O5
CAS 번호:
64439-81-2
Molecular Weight:
364.35
MDL number:
MFCD00189425
UNSPSC Code:
12352200
NACRES:
NA.77

주요 문서

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제품 이름

Camptothecin, 10-Hydroxy-, Camptotheca acuminata, A cell-permeable powerful DNA topoisomerase I inhibitor.

storage condition

OK to freeze

color

pale yellow

SMILES string

[n]21c(cc5c([c]2=O)COC(=O)C5(O)CC)c3nc4c(cc3C1)cc(cc4)O

InChI

1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3

InChI key

HAWSQZCWOQZXHI-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

관련 카테고리

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA topoisomerase I
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
A cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.

Other Notes

Zhang, X.W., et al. 1999. Anticancer Drugs.10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org.Chem.34, 1364.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H340

Hazard Classifications

Acute Tox. 3 Oral - Muta. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Mengfan Tang et al.
Nucleic acids research, 49(13), 7476-7491 (2021-07-02)
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we performed whole-genome CRISPR screens to discover genetic alterations
Venugopal R Bovilla et al.
Biomedicines, 9(9) (2021-09-29)
Nuclear factor erythroid-2 related factor-2 (Nrf2) is an oxidative stress-response transcriptional activator that promotes carcinogenesis through metabolic reprogramming, tumor promoting inflammation, and therapeutic resistance. However, the extension of Nrf2 expression and its involvement in regulation of breast cancer (BC) responses

국제 무역 품목 번호

SKUGTIN
390238-25MGCN04055977189988

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