Millipore Sigma Vibrant Logo

533872 miR-122 Inhibitor, NSC5476 - CAS 5455-90-3 - Calbiochem

Selectively down-regulates both mature miR-122 and primary miR-122 intracellular levels and reduces HIV replication.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor

Primary Target: miR-122
View Products on Sigmaaldrich.com
533872
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
5455-90-3C₁₈HN₂O₂S

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
5.33872.0001
재고 정보 검색...
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      		 Glass bottle 10 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      —
      가격 문의
      		 —
      Description
      OverviewA cell-permeable trans-decahydroquinolinylsulfonamide compound that acts as a potent, selective, and reversible inhibitor of miR-122 (EC50 = 600 nM in Huh7 cells transfected with psiCHECK-miR122 reporter plasmid). Induces a 1,250% increase in the relative luciferase signal that is indicative of strong miRNA-122 inhibition. Displays very little activity towards miR-21. Shown to down regulate the levels of mature miR-122 (by 72%) and the primary miR-122 (down to 3%). Shown to reduce hepatitis C virus (HCV) replication in Huh7 cells (47% reduction at 10 µM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533872
      Brand Family Calbiochem®
      SynonymsNSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor
      DescriptionmiR-122 Inhibitor, NSC5476
      References
      ReferencesYoung, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
      Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.
      Product Information
      CAS number5455-90-3
      FormWhite solid
      Hill FormulaC₁₈HN₂O₂S
      Chemical formulaC₁₈HN₂O₂S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmiR-122
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      5.33872.0001 04055977286809

      Documentation

      miR-122 Inhibitor, NSC5476 - CAS 5455-90-3 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      References

      참고문헌 보기
      Young, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
      Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2016 JSW
      SynonymsNSC-5476, MLS000736518, microRNA-122 Inhibitor, 6-[(4aR,8aS)-(Octahydroquinolin-1(2H)-ylsulfonyl)-1,2,3,4-tetrahydroquinoline, 6-[(4aR,8aS)-(Octahydro-1(2H)-quinolinylsulfonyl)-1,2,3,4-tetrahydroquinoline, pri-miR-122 Transcription Inhibitor, miR-122 Inhibitor
      DescriptionA cell-permeable trans-decahydroquinolinylsulfonamide compound that downregulates the liver-specific microRNA miR-122 level and pri-miR-122 production in Huh7 cells (by 72% & 93%, respectively; 10 µM for 48 h) without interaction with pre-miR-123 or affecting cellular miR-21 level. Selectively prevents miR-122-, but not miR-21-, mediated reporter transcription blockage (10 µM for 48 h) and suppresses HCV replication (by 53%; 10 µM inhibitor added 4 h post H77c/H77c/QR/KR/FV/SI RNA transfection for 48 h) in Huh7 cultures without affecting Huh7 proliferation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5455-90-3
      Chemical formulaC₁₈HN₂O₂S
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYoung, D.D., et al. 2010. J. Am. Chem. Soc. 132, 7976.
      Connelly, C.M., et al. 2012. J. Biomol. Screen. 17, 822.