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681665 Wnt Agonist - CAS 853220-52-7 - Calbiochem

Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).

Wnt Agonist - CAS 853220-52-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I

Primary Target: Selective activator of Wnt signaling
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681665
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개요

Replacement Information

주요 사양표

CAS #Empirical Formula
853220-52-7C₁₉H₁₈N₄O₃

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681665-5MGCN
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC50 > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
      Catalogue Number681665
      Brand Family Calbiochem®
      Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
      References
      ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
      Product Information
      CAS number853220-52-7
      ATP CompetitiveN
      FormYellowish sticky solid
      Hill FormulaC₁₉H₁₈N₄O₃
      Chemical formulaC₁₉H₁₈N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationWnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
      Biological Information
      Primary TargetSelective activator of Wnt signaling
      Primary Target IC<sub>50</sub>EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      681665-5MGCN 04055977260236

      Documentation

      Wnt Agonist - CAS 853220-52-7 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Wnt Agonist - CAS 853220-52-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      681665

      References

      참고문헌 보기
      Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
      DescriptionA cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development.
      FormYellowish sticky solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number853220-52-7
      Chemical formulaC₁₉H₁₈N₄O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.