수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

681535 Sigma-AldrichWithaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Primary Target: A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

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개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
5119-48-2	C₂₈H₃₈O₆

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
681535-1MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	1 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가
681535-5MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	5 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Catalogue Number	681535
Brand Family	Calbiochem®

References
References	Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

Product Information
CAS number	5119-48-2
ATP Competitive	N
Form	White solid
Hill Formula	C₂₈H₃₈O₆
Chemical formula	C₂₈H₃₈O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Primary Target IC<sub>50</sub>	12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	KE7288500

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
681535-1MGCN	04055977260113
681535-5MGCN	04055977260120

Documentation

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem Certificates of Analysis

Title	Lot Number
681535	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-September-2008 RFH
Description	A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	5119-48-2
RTECS	KE7288500
Chemical formula	C₂₈H₃₈O₆
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

카테고리

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

해당 제품은 고객님의 카트에 추가되었습니다.