Millipore Sigma Vibrant Logo

532628 Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem

A cell-permeable, highly potent, selective, and reversible inhibitor of Vps34 activity (IC₅₀ = 25 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor

Primary Target: Vps34
532628
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
1383716-33-3C₂₁H₂₄ClN₇O

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
5.32628.0001
재고 정보 검색...
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      		 Glass bottle 5 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      —
      가격 문의
      		 —
      Description
      OverviewA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532628
      Brand Family Calbiochem®
      Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
      References
      ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.
      Product Information
      CAS number1383716-33-3
      FormWhite powder
      Hill FormulaC₂₁H₂₄ClN₇O
      Chemical formulaC₂₁H₂₄ClN₇O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVps34
      Primary Target IC<sub>50</sub>25 nM using recombinant Vsp34:Vps15 complex
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      5.32628.0001 04055977281835

      Documentation

      Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      References

      참고문헌 보기
      Bago, R., et al. 2014. Biochem. J. 463, 413.

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2015 JSW
      Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
      DescriptionA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1383716-33-3
      Chemical formulaC₂₁H₂₄ClN₇O
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.