수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

645900 Sigma-AldrichTriptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: PG490

Primary Target: Activate DEVD-cleaving caspases

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개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
38748-32-2	C₂₀H₂₄O₆

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
645900-1MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	1 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가
645900-5MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	5 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
Catalogue Number	645900
Brand Family	Calbiochem®
Synonyms	PG490

References
References	Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.

Product Information
CAS number	38748-32-2
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₀H₂₄O₆
Chemical formula	C₂₀H₂₄O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Activate DEVD-cleaving caspases
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	YK7751000

Safety Information
R Phrase	R: 20/21/22-40 Harmful by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect.
S Phrase	S: 22-36 Do not breathe dust. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
645900-1MGCN	04055977262193
645900-5MGCN	04055977262209

Documentation

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem Certificates of Analysis

Title	Lot Number
645900	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-May-2009 RFH
Synonyms	PG490
Description	A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	38748-32-2
RTECS	YK7751000
Chemical formula	C₂₀H₂₄O₆
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
References	Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.

카테고리

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Immunomodulators

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