Millipore Sigma Vibrant Logo

598226 Thiostrepton - CAS 1393-48-2 - Calbiochem

Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.

Thiostrepton - CAS 1393-48-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: FOXM1 Inhibitor I

Primary Target: EF-G
View Products on Sigmaaldrich.com
598226
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
1393-48-2C₇₂H₈₅N₁₉O₁₈S₅

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
598226-10GMCN
재고 정보 검색...
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      		 Glass bottle 10 gm
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      —
      가격 문의
      		 —
      598226-1GMCN
      재고 정보 검색...
      —
      현재 재고 없음 현재 재고 없음
      예상 출고 가능일 
      단종품
      제한된 수량 가능
      재고여부 확인
        Remaining: will advise
          Remaining: will advise
          추천사항
          고객 서비스로 문의
          Contact Customer Service

          		 Plastic ampoule 1 gm
          가격 검색...
          가격을 검색할 수 없습니다
          Minimum Quantity needs to be mulitiple of
          Maximum Quantity is
          가격 문의 추가 정보
          ()이 할인됨
           
          —
          가격 문의
          		 —
          Description
          OverviewA thiazole-containing peptide antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Inhibits the function of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome. The thiostrepton-resistant gene is also commonly used as a selective marker for recombinant DNA/plasmid technologies.
          Catalogue Number598226
          Brand Family Calbiochem®
          SynonymsFOXM1 Inhibitor I
          References
          ReferencesRodnina, M.V., et al. 1999. Proc. Natl. Acad. Sci USA 96, 9586.
          Rosendahl, G. and Douthwaite, S. 1994. Nucleic Acids Res. 22, 357.
          Saarma, U. and Remme, J. 1992. Nucleic Acids Res. 20, 3147.
          Malina, H. and Robert-Gero, M. 1992. Appl. Environ. Microbiol. 58, 895.
          Blanco, G., et al. 1992. Gene 112, 59.
          Miller, S.P. and Bodley, J.W. 1991. Nucleic Acids Res. 19, 1657.
          Ryan, P.C., et al. 1991. J. Mol. Biol. 221, 1257.
          Kutay, U.R., et al. 1990. Biochim. Biophys. Acta 1050, 193.
          Smokvina, T., et al. 1990. Gene 94, 53.
          Garrett, R. 1983. Trends Biochem. Sci. 8, 189.
          Bodley, J.W., et al. 1970. Biochem. Biophys. Res. Commun. 41, 1406.
          Thompson, J. and Cundliffe, E. 1970. Biochimie 73, 1131.
          Product Information
          CAS number1393-48-2
          FormOff-white powder
          Hill FormulaC₇₂H₈₅N₁₉O₁₈S₅
          Chemical formulaC₇₂H₈₅N₁₉O₁₈S₅
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetEF-G
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSXN6300100
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          카탈로그 번호 GTIN
          598226-10GMCN 04055977189162
          598226-1GMCN 07790788051914

          Documentation

          Thiostrepton - CAS 1393-48-2 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Thiostrepton - CAS 1393-48-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          598226

          References

          참고문헌 보기
          Rodnina, M.V., et al. 1999. Proc. Natl. Acad. Sci USA 96, 9586.
          Rosendahl, G. and Douthwaite, S. 1994. Nucleic Acids Res. 22, 357.
          Saarma, U. and Remme, J. 1992. Nucleic Acids Res. 20, 3147.
          Malina, H. and Robert-Gero, M. 1992. Appl. Environ. Microbiol. 58, 895.
          Blanco, G., et al. 1992. Gene 112, 59.
          Miller, S.P. and Bodley, J.W. 1991. Nucleic Acids Res. 19, 1657.
          Ryan, P.C., et al. 1991. J. Mol. Biol. 221, 1257.
          Kutay, U.R., et al. 1990. Biochim. Biophys. Acta 1050, 193.
          Smokvina, T., et al. 1990. Gene 94, 53.
          Garrett, R. 1983. Trends Biochem. Sci. 8, 189.
          Bodley, J.W., et al. 1970. Biochem. Biophys. Res. Commun. 41, 1406.
          Thompson, J. and Cundliffe, E. 1970. Biochimie 73, 1131.

          Brochure

          Title
          Antibiotics Profiler

          Citations

          타이틀
        • Sarae L. Bausch, Ekaterina Poliakova and David E. Draper. (2005) Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA. Journal of Biological Chemistry 280, 29956-29963.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-August-2014 JSW
          SynonymsFOXM1 Inhibitor I
          DescriptionA thiazole-containing polypeptide antibiotic isolated from Streptomyces azureus. Inhibits bacterial protein synthesis and ribosomal GTPase activity by binding noncovalently, but virtually irreversibly, to the 23S rRNA in the GTPase center of the 50S subunit. Thiostrepton binding directly prevents binding to the ribosome of elongation factor G (EF-G), which also binds specifically to the 23S rRNA. Thiostrepton has proved useful in elucidating the molecular mechanisms of translation, particularly of ribosomal translocation. It is also used for selection, in bacteria of Streptomyces sp., of vectors containing the tsr gene (S. azureus), which encode a 23S rRNA methylase whose action prevents thiostrepton from binding to ribosomes.
          FormOff-white powder
          CAS number1393-48-2
          RTECSXN6300100
          Chemical formulaC₇₂H₈₅N₁₉O₁₈S₅
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml) or Chloroform (10 mg/ml)
          Storage Protect from moisture
          Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 9364
          ReferencesRodnina, M.V., et al. 1999. Proc. Natl. Acad. Sci USA 96, 9586.
          Rosendahl, G. and Douthwaite, S. 1994. Nucleic Acids Res. 22, 357.
          Saarma, U. and Remme, J. 1992. Nucleic Acids Res. 20, 3147.
          Malina, H. and Robert-Gero, M. 1992. Appl. Environ. Microbiol. 58, 895.
          Blanco, G., et al. 1992. Gene 112, 59.
          Miller, S.P. and Bodley, J.W. 1991. Nucleic Acids Res. 19, 1657.
          Ryan, P.C., et al. 1991. J. Mol. Biol. 221, 1257.
          Kutay, U.R., et al. 1990. Biochim. Biophys. Acta 1050, 193.
          Smokvina, T., et al. 1990. Gene 94, 53.
          Garrett, R. 1983. Trends Biochem. Sci. 8, 189.
          Bodley, J.W., et al. 1970. Biochem. Biophys. Res. Commun. 41, 1406.
          Thompson, J. and Cundliffe, E. 1970. Biochimie 73, 1131.
          Citation
        • Sarae L. Bausch, Ekaterina Poliakova and David E. Draper. (2005) Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA. Journal of Biological Chemistry 280, 29956-29963.
          		•