1.50448
SeQuant® ZIC®-HILIC 200Å (3.5 µm) HPLC Columns
L × I.D. 150 mm x 2.1 mm HPLC Column, PEEK-lined stainless steel
동의어(들):
Zwitterionic Hydrophilic Interaction Liquid Chromatography HPLC Column
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제품정보 (DICE 배송 시 비용 별도)
UNSPSC Code:
41115709
NACRES:
NB.21
Particle size:
3.5 μm
Matrix active group:
ZIC-HILIC, ZIC-HILIC bonding phase
Pore size:
200 Å pore size
Matrix:
fully porous particle
제품 이름
SeQuant® ZIC-HILIC™ 3.5µm,200Å 150 x 2.1 mm, PEEK-lined stainless steel column, suitable for HPLC
material
PEEK-lined stainless steel column
Quality Segment
agency
suitable for USP L114
product line
SeQuant®
feature
endcapped: no
parameter
550 bar pressure, 70 °C max. temp.
technique(s)
HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable, mass spectrometry (MS): suitable (High)
column L × I.D.
15 cm × 2.1 mm
matrix
fully porous particle
matrix active group
ZIC-HILIC, ZIC-HILIC bonding phase
particle size
3.5 μm
pore size
200 Å pore size
operating pH
2-7.5
separation technique
hydrophilic interaction (HILIC)
storage temp.
no temp limit
General description
SeQuant® ZIC®-HILIC Columns are designed to retain and separate all types of polar and hydrophilic compounds and for robust chromatography with high selectivity and reproducibility. The silica-based ZIC®-HILIC sorbent has a bonded stationary phase consisting of a highly polar, permanent zwitterion. Separation selectivity is favored by the 1:1 zwitterion charge balance, which makes the ZIC®-HILIC Column overall neutral, with weak, but important, ionic interactions. Tuning of the selectivity on the ZIC®-HILIC Column during method development is facilitated by the pH-inpendent permanent zwitterion, ensuring that only the analytes (and not the column) are affected during eluent optimization.The Pore size of 200 Å makes this column perfectly suitable for the separation of larger polar molecules under HILIC conditions.The column dimension of 150 mm length x 2.1 mm ID is the optimal choice for the separation of polar compounds using a UHPLC or optimized HPLC Instrument providing low dwell volumes.Thanks to their favorable retention and robust performance, SeQuant® HILIC columns have become extremely popular in numerous laboratories around the world. For example, US FDA (United States Food and Drug Administration) has recommended SeQuant® ZIC®-HILIC for analysis of melamine and related substances. SeQuant® HILIC columns excel in stability and low bleed. These features make them particularly suitable for LC-MS applications where high background can lead to signal suppression and interference with quantitative measurements while also increasing instrument wear. Their high stability makes these high-performance HILIC columns also attractive for traditional HPLC applications.Learn more about the Supelco HPLC Column portfolio and Method development:Brochure: HPLC and UHPLC Column Selection Guide Brochure: A Practical Guide to HPLC - Method Development Guide
Application
- Click postsynthesis of microporous organic network@silica composites: Demonstrates the application of SeQuant ZIC-HILI columns in mixed-mode chromatography, particularly in the synthesis of composites that facilitate both reversed-phase and hydrophilic interaction chromatography. This approach is crucial for advanced pharmaceutical compound analysis and biomolecule separation technology (Sun HF et al., 2023).
- Evaluation of Hold-Up Volume Determination Methods and Markers in Hydrophilic Interaction Liquid Chromatography: Focuses on refining the precision in volume determinations using ZIC-HILIC columns, enhancing method development for pharmaceuticals and providing a basis for high-resolution mass spectrometry applications (Redon L et al., 2023).
- Determination of the polyphenolic content of berry juices: Utilizes SeQuant ZIC-HILIC technology for comprehensive two-dimensional liquid chromatography, essential for complex sample analysis in food safety and quality assessments (Arena K et al., 2023).
- Simple and sensitive determination of sulfites in Chinese herbal teas: Highlights the robustness of SeQuant ZIC-HILIC in ultra-high-performance liquid chromatography tandem mass spectrometry, ensuring the safety and compliance of herbal products with stringent health standards (Yang L et al., 2022).
Analysis Note
Theoretical Plates (N/m) (Cytosine): ≥ 90000
Symmetry (Cytosine): 0.95 - 1.40
Symmetry (Cytosine): 0.95 - 1.40
Legal Information
SeQuant is a registered trademark of Merck KGaA, Darmstadt, Germany
ZIC is a registered trademark of Merck KGaA, Darmstadt, Germany
ZIC-HILIC is a trademark of Merck KGaA, Darmstadt, Germany
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시험 성적서(COA)
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