500519 Sigma-AldrichSKP2 E3 Ligase Inhibitor I, C1 - CAS 432001-69-9 - Calbiochem
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Primary Target:
disrupts p27-Skp2 interaction
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid, p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I
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개요
주요 사양표
| CAS # | Empirical Formula |
|---|---|
| 432001-69-9 | C₁₈H₁₃BrN₂O₄S₂ |
가격 및 재고여부
| 카탈로그 번호 | 재고 정보 | 패킹 | 포장 단위 | 가격(VAT 별도) | 수량 | |
|---|---|---|---|---|---|---|
| 5.00519.0001 |
|
Glass bottle | 25 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10 µM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) complex. Shown to inhibit the proliferation of human breast cancer MCF-7 and melanoma 501 Mel cells (IC50 = 8 and 30 µM, respectively; 16 h incubation). Unlike SMIP004 (Cat. No. 500517), C1 does not affect cellular Cyclin E/CDK2 kinase activity or Skp2 level. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500519 |
| Brand Family | Calbiochem® |
| Synonyms | (Z)-2-(4-Bromo-2-((4-oxo-3-(pyridin-3-ylmethyl)-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid, p21/Cip1/Waf1 Activator I; p27/Kip1 Activator I, S-phase Kinase-associated Protein 2 Inhibitor I; SCFSKP2 Inhibitor I, CRL1SKP2 Inhibitor I |
| References | |
|---|---|
| References | Rico-Bautista, E., and Wolf, D.A. 2012. Chem. Biol. 19, 1497. Wu, L., et al. 2012. Chem. Biol. 19, 1515. |
| Product Information | |
|---|---|
| CAS number | 432001-69-9 |
| Form | Orange brown powder |
| Hill Formula | C₁₈H₁₃BrN₂O₄S₂ |
| Chemical formula | C₁₈H₁₃BrN₂O₄S₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | disrupts p27-Skp2 interaction |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| 카탈로그 번호 | GTIN |
| 5.00519.0001 | 04055977245752 |