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RI-13K Rat Insulin RIA

RI-13K
250 tubes  
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      개요

      주요 사양표

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      Insulin RRIARadioactive 125I
      Description
      Catalogue NumberRI-13K
      DescriptionRat Insulin RIA
      Background InformationInsulin, a 5.8 kD hormone is secreted by the islet beta cells in the pancreas.
      Product Information
      Detection methodRadioactive 125I
      Performance
      • ED80 = 0.2 ± 0.02 ng/mL
        ED50 = 0.8 ± 0.04 ng/mL
        ED20 = 3.0 ± 0.36 ng/mL
      Precision, %
      • Inter-assay: 8.5–9.4
      • Intra-assay: 1.4–4.6
      Quality LevelMQ100
      Applications
      ApplicationThis radioimmunoassay (RIA) measures & quantifies Insulin for use in Metabolism & Endocrine research.
      Key Applications
      • Radioimmunoassay
      Application NotesOvernight, equilibrium incubation at 4º C. Sample volume 100 μL serum, plasma, or tissue culture media.
      Biological Information
      SpecificityRat Insulin I 100% Rat Insulin II 100% Human Insulin 100% Human Proinsulin 69% Procine Insulin 100% Sheep Insulin 100% Hamster Insulin 100% Mouse Insulin 100% Rat C-Peptide Not Detectabl Glucagon Not Detectable Somatostatin Not Detectable Pancr
      Species Reactivity
      • Rat
      Analytes Available
      • Insulin
      Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Radioactive Isotype125I-Insulin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Accuracy
      • 85–93%
      Physicochemical Information
      Linearity of Dilution80 -100%
      Standard Curve Range
      • 0.1–10 ng/mL
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Packaging Information
      Material Size250 tubes
      Global Trade Item Number
      카탈로그 번호 GTIN
      RI-13K 04053252578991