수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

553502 Sigma-AldrichRac1 Inhibitor - CAS 1177865-17-6 - Calbiochem

Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet
Citations

Synonyms: NSC23766

Primary Target: Rac1

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개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
1177865-17-6	C₂₄H₃₈Cl₃N₇

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
553502-10MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Glass bottle	10 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가
553502-5MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	5 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC₅₀ ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC₅₀ = 50 mM and 64 mM, respectively).
Catalogue Number	553502
Brand Family	Calbiochem®
Synonyms	NSC23766

References
References	Dwivedi, S., et al. 2010. J. Translational Med. 8, 128. Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

Product Information
CAS number	1177865-17-6
ATP Competitive	N
Form	Lyophilized
Hill Formula	C₂₄H₃₈Cl₃N₇
Chemical formula	C₂₄H₃₈Cl₃N₇
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Rac1
Primary Target IC<sub>50</sub>	~50 µM against Rac1 GDP/GTP exchange activity; 50 mM and 64 mM against TRAP-induced and collagen stimulated platelet aggregation
Purity	≥93% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
553502-10MGCN	04055977193626
553502-5MGCN	07790788051433

Documentation

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

Rac1 Inhibitor - CAS 1177865-17-6 - Calbiochem Certificates of Analysis

Title	Lot Number
553502	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Dwivedi, S., et al. 2010. J. Translational Med. 8, 128. Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.

Citations

타이틀

Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	NSC23766
Description	A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC₅₀ ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1. Reduces TRAP-induced and collagen stimulated platelet aggregation (IC₅₀ = 50 mM and 64 mM, respectively).
Form	Lyophilized
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1177865-17-6
Chemical formula	C₂₄H₃₈Cl₃N₇
Structure formula
Purity	≥93% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Dwivedi, S., et al. 2010. J. Translational Med. 8, 128. Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618.
Citation	Dwivedi, S., et al. 2010. J. Translational Med. 8, 128.

카테고리

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rac Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > GTPase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > G-Protein Coupled Receptor Agonists

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