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Merck

559285

RSK Inhibitor, SL0101

The RSK Inhibitor, SL0101 controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

동의어(들):

RSK Inhibitor, SL0101, Kaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C25H24O12
CAS 번호:
77307-50-7
Molecular Weight:
516.45
MDL number:
MFCD09842349
UNSPSC Code:
12352200
NACRES:
NA.77

주요 문서

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제품 이름

RSK Inhibitor, SL0101, The RSK Inhibitor, SL0101 controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SMILES string

O1[C@H]([C@@H]([C@@H]([C@H]([C@@H]1C)OC(=O)C)OC(=O)C)O)Oc2[c](c3c([o]c2c4ccc(cc4)O)cc(cc3O)O)=O

InChI

1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1

InChI key

SXOZSDJHGMAEGZ-IGKKHSBFSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

관련 카테고리

Disclaimer

Toxicity: Regulatory Review (Z)

General description

A cell-permeable Kaempferol glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. Also available as a 10 mM solution in DMSO (Cat. No. 559292).

Other Notes

Smith, J.A., et al. 2007. Bioorg. Med. Chem.15, 5018.
Smith, J.A., et al. 2006. Bioorg. Med. Chem.14, 6043.
Xu, Y.M., et al. 2006. Bioorg. Med. Chem.14, 3974.
Maloney, D.J. and Hecht, S.M., 2005. Org. Lett.7, 1097.
Smith, J.A., et al. 2005. Cancer Res.65, 1027.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Mohamed Mahameed et al.
Biotechnology and bioengineering, 116(3), 569-580 (2018-12-05)
Protein translation has emerged as a critical bottleneck for overall productivity of biological molecules. An augmentation of protein translation can be achieved by cell line engineering or by sophisticated vector design. However, for industrial process development purposes, identification of media
Coralie Dessauges et al.
Molecular systems biology, 18(6), e10670-e10670 (2022-06-14)
Combining single-cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an ERK biosensor to measure single-cell ERK dynamics. This allowed us

국제 무역 품목 번호

SKUGTIN
559285-1MGCN04055977192360

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