553525 Sigma-AldrichRAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem
The RAD51 Inhibitor, B02 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The RAD51 Inhibitor, B02 controls the biological activity of RAD51. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one
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개요
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주요 사양표
| CAS # | Empirical Formula |
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| 1290541-46-6 | C₂₂H₁₇N₃O |
가격 및 재고여부
| 카탈로그 번호 | 재고 정보 | 패킹 | 포장 단위 | 가격(VAT 별도) | 수량 | |
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| 553525-25MGCN |
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Glass bottle | 25 mg |
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| Description | |
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| Overview | A cell-permeable pyridinylvinyl-quinazolinone compound that is shown to specifically inhibit human RAD51 (IC50 = 27.4 µM). Does not affect RecA even at much higher concentration (~250 µM). Directly interacts with RAD51 (Kd = 5.6 µM), and disrupts its binding to DNA and nucleoprotein filament formation. Blocks double-strand break-induced homologous recombination and enhances sensitivity of cells to Cisplatin (Cat. No. 232120) and Mitomycin C (Cat. No. 47589), (Cat. No. 475820). Diminishes co-aggregate formation between RAD51-ssDNA filament and dsDNA. RAD51-Stimulatory Compound-1, RS-1 (Cat. No. 553510) is also available. |
| Catalogue Number | 553525 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-3-Benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one |
| References | |
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| References | Huang, F., et al. 2012. J. Med. Chem. 55, 3031. Huang, F., et al. 2011. ACS Chem. Biol. 6, 628. |
| Product Information | |
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| CAS number | 1290541-46-6 |
| Form | Light yellow powder |
| Hill Formula | C₂₂H₁₇N₃O |
| Chemical formula | C₂₂H₁₇N₃O |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 카탈로그 번호 | GTIN |
| 553525-25MGCN | 04055977193749 |
Documentation
RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem MSDS
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RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 553525 |
References
| 참고문헌 보기 |
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| Huang, F., et al. 2012. J. Med. Chem. 55, 3031. Huang, F., et al. 2011. ACS Chem. Biol. 6, 628. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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