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370653 PknG Inhibitor - CAS 329221-38-7 - Calbiochem

The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017

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370653
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개요

Replacement Information

주요 사양표

CAS #Empirical Formula
329221-38-7C₁₃H₁₆N₂O₂S

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카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
370653-10MGCN
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      		 Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
      Catalogue Number370653
      Brand Family Calbiochem®
      SynonymsMycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
      References
      ReferencesScherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
      Walburger, A., et al. 2004. Science 304, 1800.
      Product Information
      CAS number329221-38-7
      FormLight brown solid
      Hill FormulaC₁₃H₁₆N₂O₂S
      Chemical formulaC₁₃H₁₆N₂O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      370653-10MGCN 04055977191639

      Documentation

      PknG Inhibitor - CAS 329221-38-7 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      PknG Inhibitor - CAS 329221-38-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      370653

      References

      참고문헌 보기
      Scherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
      Walburger, A., et al. 2004. Science 304, 1800.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsMycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
      DescriptionA cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCα, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
      FormLight brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number329221-38-7
      Chemical formulaC₁₃H₁₆N₂O₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesScherr, N., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 16388.
      Walburger, A., et al. 2004. Science 304, 1800.