Millipore Sigma Vibrant Logo

524400 Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PMA, TPA, PKC Activator I

Primary Target: Protein Kinase C
View Products on Sigmaaldrich.com
524400
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
16561-29-8C₃₆H₅₆O₈

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
524400-10MGCN
재고 정보 검색...
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      		 Glass bottle 10 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      —
      가격 문의
      		 —
      524400-1MGCN
      재고 정보 검색...
      —
      현재 재고 없음 현재 재고 없음
      예상 출고 가능일 
      단종품
      제한된 수량 가능
      재고여부 확인
        Remaining: will advise
          Remaining: will advise
          추천사항
          고객 서비스로 문의
          Contact Customer Service

          		 Glass bottle 1 mg
          가격 검색...
          가격을 검색할 수 없습니다
          Minimum Quantity needs to be mulitiple of
          Maximum Quantity is
          가격 문의 추가 정보
          ()이 할인됨
           
          —
          가격 문의
          		 —
          524400-25MGCN
          재고 정보 검색...
          —
          현재 재고 없음 현재 재고 없음
          예상 출고 가능일 
          단종품
          제한된 수량 가능
          재고여부 확인
            Remaining: will advise
              Remaining: will advise
              추천사항
              고객 서비스로 문의
              Contact Customer Service

              		 Glass bottle 25 mg
              가격 검색...
              가격을 검색할 수 없습니다
              Minimum Quantity needs to be mulitiple of
              Maximum Quantity is
              가격 문의 추가 정보
              ()이 할인됨
               
              —
              가격 문의
              		 —
              524400-5MGCN
              재고 정보 검색...
              —
              현재 재고 없음 현재 재고 없음
              예상 출고 가능일 
              단종품
              제한된 수량 가능
              재고여부 확인
                Remaining: will advise
                  Remaining: will advise
                  추천사항
                  고객 서비스로 문의
                  Contact Customer Service

                  		 Glass bottle 5 mg
                  가격 검색...
                  가격을 검색할 수 없습니다
                  Minimum Quantity needs to be mulitiple of
                  Maximum Quantity is
                  가격 문의 추가 정보
                  ()이 할인됨
                   
                  —
                  가격 문의
                  		 —
                  Description
                  OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
                  Catalogue Number524400
                  Brand Family Calbiochem®
                  SynonymsPMA, TPA, PKC Activator I
                  References
                  ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.
                  Product Information
                  CAS number16561-29-8
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₃₆H₅₆O₈
                  Chemical formulaC₃₆H₅₆O₈
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Applications
                  ApplicationPhorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
                  Biological Information
                  Primary TargetProtein Kinase C
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  RTECSQH4377000
                  Safety Information
                  R PhraseR: 21-38

                  Harmful in contact with skin.
                  Irritating to skin.
                  S PhraseS: 26-27-36-45

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Take off immediately all contaminated clothing.
                  Wear suitable protective clothing.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Product Usage Statements
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Transport Information
                  Supplemental Information
                  Specifications
                  Global Trade Item Number
                  카탈로그 번호 GTIN
                  524400-10MGCN 04055977270952
                  524400-1MGCN 04055977270945
                  524400-25MGCN 04055977270969
                  524400-5MGCN 04055977270976

                  Documentation

                  Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem MSDS

                  타이틀

                  물질안전보건자료(MSDS) 

                  Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem Certificates of Analysis

                  TitleLot Number
                  524400

                  References

                  참고문헌 보기
                  Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.

                  Brochure

                  Title
                  Caspases and other Apoptosis Related Tools Brochure

                  Citations

                  타이틀
                • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
                • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
                • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
                • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
                  		•
                  Data Sheet

                  Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                  Revision19-October-2010 JSW
                  SynonymsPMA, TPA, PKC Activator I
                  DescriptionExtremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
                  FormWhite solid
                  Intert gas (Yes/No) Packaged under inert gas
                  CAS number16561-29-8
                  RTECSQH4377000
                  Chemical formulaC₃₆H₅₆O₈
                  Structure formulaStructure formula
                  Purity≥98% by HPLC
                  SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
                  Storage -20°C
                  Do Not Freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
                  Toxicity Harmful
                  ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.
                  Citation
                • Cvetanovic, M., et al. 2006. Journal of Biological Chemistry 281, 20055.
                • Jafri, F., et al. 2006. Journal of Biological Chemistry 281, 19346.
                • Jiang, X., et al. 2005. Arteriosclerosis, Thrombosis, and Vascular Biology 25, 2515.
                • Yoon-Jin Lee, et al. 2005. Journal of Biological Chemistry 280, 18108.
                  		•