PKCα Protein, active, 10 µg

Research area: Apoptosis

Protein Target: PKCα

Target Sub-Family: AGC

PKCα

Recombinant, full-length human PKCα, containing N-terminal His6 tag

Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.

Protein kinase C-α (PKCα), an isoform of protein kinase C, exhibits an anti-apoptotic and pro-proliferative function. It is commonly upregulated in tumor cells, and its depletion has been associated with apoptosis induction. The anti-apoptotic effects of PKCα are mediated through mechanisms such as phosphorylation of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and activation of the pro-survival protein kinase AKT. The inhibition of PKCα leads to the activation of a PKCδ-dependent apoptotic pathway in salivary epithelial cells. PKCα regulates cell cycle progression in glioma cells by increasing the expression of p21 cyclin-dependent kinase inhibitor 1 (p21 (Waf1/Cip1)), a protein involved in cell cycle regulation.

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-484M when ordering the 250 µg size.

Ni²⁺/NTA-agarose

1 year at -70°C

routinely evaluated by phosphorylation of Histone H1.

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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