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526559 PI3Kδ Inhibitor, SW30 - Calbiochem

The PI3Kδ Inhibitor, SW30 controls the biological activity of PI3Kδ. This small molecule/inhibitor is primarily used for Membrane applications.

PI3Kδ Inhibitor, SW30 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PI 3-K Inhibitor XIV, 2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one

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526559
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical Formula
C₂₅H₂₁N₇O₂

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카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
526559-5MGCN
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      		 Glass bottle 5 mg
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      Description
      OverviewA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
      Catalogue Number526559
      Brand Family Calbiochem®
      SynonymsPI 3-K Inhibitor XIV, 2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
      References
      ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.
      Product Information
      FormWhite solid
      Hill FormulaC₂₅H₂₁N₇O₂
      Chemical formulaC₂₅H₂₁N₇O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      526559-5MGCN 04055977270334

      Documentation

      PI3Kδ Inhibitor, SW30 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      PI3Kδ Inhibitor, SW30 - Calbiochem Certificates of Analysis

      TitleLot Number
      526559

      References

      참고문헌 보기
      Williams, O., et al. 2010. Chem Biol. 17, 123.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-June-2011 RFH
      SynonymsPI 3-K Inhibitor XIV, 2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
      DescriptionA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ, PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
      FormWhite solid
      Chemical formulaC₂₅H₂₁N₇O₂
      Structure formulaStructure formula
      Purity>95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.