수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

528150 Sigma-AldrichPARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem

PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Primary Target: PARP

Recommended Products

개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
344458-15-7	C₁₇H₁₇N₃O₂ · HCl

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
528150-1MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	1 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가
528150-5MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Plastic ampoule	5 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC₅₀ = 200 µM). Does not act as an antioxidant at higher concentrations (1 µM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H₂O(Cat. No. 528151).
Catalogue Number	528150
Brand Family	Calbiochem®

References
References	Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

Product Information
CAS number	344458-15-7
ATP Competitive	N
Form	White solid
Hill Formula	C₁₇H₁₇N₃O₂ · HCl
Chemical formula	C₁₇H₁₇N₃O₂ · HCl
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	PARP Inhibitor VIII, PJ34, CAS 344458-15-7, is a cell-permeable, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM).

Biological Information
Primary Target	PARP
Primary Target IC<sub>50</sub>	EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
528150-1MGCN	04055977196405
528150-5MGCN	04055977196412

Documentation

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem Certificates of Analysis

Title	Lot Number
528150	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-January-2008 JSW
Description	A water-soluble phenanthridinone-derivative that acts as a potent anti-inflammatory agent and an inhibitor of poly(ADP-ribose) polymerase (PARP; EC₅₀ = 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC₅₀ = 200 µM). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 µM to 10 µM). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC₅₀ = 20 nM). Exhibits neuroprotective effects in in vivo and in vitro models of stroke.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	344458-15-7
Chemical formula	C₁₇H₁₇N₃O₂ · HCl
Structure formula
Purity	≥98% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Abdelkarim, G.E., et al. 2001. Int. J. Mol. Med. 7, 255. Garcia-Soriano, F.G., et al. 2001. Nature Med. 7, 108. Mabley, G.J., et al. 2001. Inflamm. Res. 50, 561.

카테고리

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Poly(ADP-ribose) Polymerase (PARP) and Poly(ADP-ribose) Glycohydrolase (PARG) Inhibitors

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