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480060 Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem

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480060
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주요 사양표

CAS #Empirical Formula
861891-50-1C₁₉H₂₃N₃O₂

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480060-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
      Catalogue Number480060
      Brand Family Calbiochem®
      Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
      References
      ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
      Product Information
      CAS number861891-50-1
      ATP CompetitiveN
      FormYellow orange solid
      Hill FormulaC₁₉H₂₃N₃O₂
      Chemical formulaC₁₉H₂₃N₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBlocks oxidative stress-induced necrotic cell death
      Primary Target IC<sub>50</sub>(~3 µM prevented ~50% cell death in HL60 cells exposed to 100 µM H₂O₂).
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      480060-5MGCN 04055977201864

      Documentation

      Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem MSDS

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      물질안전보건자료(MSDS) 

      Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      480060

      References

      참고문헌 보기
      Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
      DescriptionA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
      FormYellow orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number861891-50-1
      Chemical formulaC₁₉H₂₃N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.