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492030 NS 2028 - CAS 204326-43-2 - Calbiochem

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

NS 2028 - CAS 204326-43-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one

Primary Target: basal soluble guanylyl cyclase
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492030
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개요

Replacement Information

주요 사양표

CAS #Empirical Formula
204326-43-2C₉H₅BrN₂O₃

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492030-5MGCN
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      		 Plastic ampoule 5 mg
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      Description
      OverviewPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
      Catalogue Number492030
      Brand Family Calbiochem®
      Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
      References
      ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
      Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.
      Product Information
      CAS number204326-43-2
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₉H₅BrN₂O₃
      Chemical formulaC₉H₅BrN₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetbasal soluble guanylyl cyclase
      Primary Target IC<sub>50</sub>30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      492030-5MGCN 04055977273557

      Documentation

      NS 2028 - CAS 204326-43-2 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      NS 2028 - CAS 204326-43-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      492030

      References

      참고문헌 보기
      Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
      Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
      DescriptionPotent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
      FormWhite to off-white solid
      CAS number204326-43-2
      Chemical formulaC₉H₅BrN₂O₃
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), or CHCl₃ (1 mg/ml)
      Storage Protect from moisture
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesFleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
      Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.