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481408 NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine

Primary Target: Blocks nuclear translocation of NF-κB p65 and its transcription activity
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481408
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개요

주요 사양표

CAS #Empirical Formula
749886-87-1C₁₆H₂₀N₂

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481408-5MGCN
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
      Catalogue Number481408
      Brand Family Calbiochem®
      Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
      References
      ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.
      Product Information
      CAS number749886-87-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₂₀N₂
      Chemical formulaC₁₆H₂₀N₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
      Biological Information
      Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
      Primary Target IC<sub>50</sub>7.1 µM in a NF-κB reporter assay using RAW 264.7
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      카탈로그 번호 GTIN
      481408-5MGCN 07790788050672