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475879 Monastrol - CAS 254753-54-3 - Calbiochem

A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.

Monastrol - CAS 254753-54-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I

Primary Target: Mitotic kinesin Eg5
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475879
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
254753-54-3C₁₄H₁₆N₂O₃S

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
475879-1MGCN
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      		 Plastic ampoule 1 mg
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      475879-5MGCN
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          		 Plastic ampoule 5 mg
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          Description
          OverviewA potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
          Catalogue Number475879
          Brand Family Calbiochem®
          Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
          References
          ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.
          Product Information
          CAS number254753-54-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₄H₁₆N₂O₃S
          Chemical formulaC₁₄H₁₆N₂O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetMitotic kinesin Eg5
          Primary Target IC<sub>50</sub>14 µM against mitotic kinesin Eg5
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          카탈로그 번호 GTIN
          475879-1MGCN 04055977203479
          475879-5MGCN 04055977203486

          Documentation

          Monastrol - CAS 254753-54-3 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Monastrol - CAS 254753-54-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          475879

          References

          참고문헌 보기
          Kapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
          DescriptionA potent, cell-permeable, nontubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number254753-54-3
          Chemical formulaC₁₄H₁₆N₂O₃S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
          Mayer, T.U., et al. 1999. Science 286, 971.