Millipore Sigma Vibrant Logo

407272 Integrin αvβ3 Antagonist, P11 - Calbiochem

The Integrin αvβ3 Antagonist, P11 controls the biological activity of Integrin αvβ3.

Integrin αvβ3 Antagonist, P11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HSDVHK-NH2, HSDVHK

View Products on Sigmaaldrich.com
407272
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical Formula
C₃₀H₅₁N₁₂O₉₃· 3TFA

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
407272-5MGCN
재고 정보 검색...
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      		 Glass bottle 5 mg
      가격 검색...
      가격을 검색할 수 없습니다
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      가격 문의 추가 정보
      ()이 할인됨
       
      —
      가격 문의
      		 —
      Description
      OverviewA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
      Catalogue Number407272
      Brand Family Calbiochem®
      SynonymsHSDVHK-NH2, HSDVHK
      References
      ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoracetate salt.
      Hill FormulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      407272-5MGCN 04055977188769

      Documentation

      Integrin αvβ3 Antagonist, P11 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Integrin αvβ3 Antagonist, P11 - Calbiochem Certificates of Analysis

      TitleLot Number
      407272

      References

      참고문헌 보기
      Bang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-jul-2012
      SynonymsHSDVHK-NH2, HSDVHK
      DescriptionA cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin αvβ3 (IC50 = 1.74 pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37 °C, a process which is mediated by caveolin and clathrin. At 10 µg/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50 µg/ml.
      FormWhite solid
      FormulationSupplied as a trifluoracetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₁N₁₂O₉₃· 3TFA
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBang, J., et al. 2011. Mol Cell Proteomics 10, M110.
      Choi, Y., et al. 2010. Proteomics 10, 72.
      Lee, Y., et al. 2004. J. Biomol. Screen. 9, 687.