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124038 InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

The InSolution™ Akt Inhibitor V, Triciribine, also referenced under CAS 35943-35-2, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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124038
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
35943-35-2C₁₃H₁₆N₆O₄

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
124038-2MGCN
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      		 Glass bottle 2 mg
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      Description
      OverviewA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
      Catalogue Number124038
      Brand Family Calbiochem®
      References
      ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.
      Product Information
      CAS number35943-35-2
      FormLiquid
      FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
      Hill FormulaC₁₃H₁₆N₆O₄
      Chemical formulaC₁₃H₁₆N₆O₄
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRY8455000
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      124038-2MGCN 04055977205848

      Documentation

      InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      124038

      References

      참고문헌 보기
      Karst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-January-2012 RFH
      DescriptionA cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
      FormLiquid
      FormulationA 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number35943-35-2
      RTECSRY8455000
      Chemical formulaC₁₃H₁₆N₆O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-70°C).
      Toxicity Irritant
      ReferencesKarst, A., et al. 2006. Cancer Res. 66, 9225.
      Yang, L., et al. 2004. Cancer Res. 64, 4394.