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382187 HDAC Inhibitor XXIII, Tubastatin A - Calbiochem

The HDAC Inhibitor XXIII, Tubastatin A controls the biological activity of HDAC. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide

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382187
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개요

주요 사양표

Empirical Formula
C₂₀H₂₁N₃O₂

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382187-5MGCN
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      		 Glass bottle 5 mg
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      Description
      OverviewA cell-permeable carbazolohydroxamate that acts as a highly potent HDAC6-selective inhibitor (IC50 = 15 nM) with much reduced or no activity against other known HDACs. Effectively prevents neuronal cell death (by ≥95% at 10 µM) upon oxidative stress induction by HCA and selectively induces cellular α-tubulin, but not histone H4, hyperacetylation (2.5 to 5 µM) in primary rat cortical neuron cultures.
      Catalogue Number382187
      Brand Family Calbiochem®
      SynonymsN-Hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide
      References
      ReferencesButler, K.V., et al. 2010. J. Am. Chem. Soc. 132, 10842.
      Product Information
      FormTan solid
      Hill FormulaC₂₀H₂₁N₃O₂
      Chemical formulaC₂₀H₂₁N₃O₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      카탈로그 번호 GTIN
      382187-5MGCN 04055977212860