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370677 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem

A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Rp-8-pCPT-cGMPS, TEA, PKG Inhibitor III

Primary Target: PKG1α
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370677
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical Formula
C₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
370677-1UMOLCN
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      		 Plastic ampoule 1 umol
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      Description
      OverviewA potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg.
      Catalogue Number370677
      Brand Family Calbiochem®
      SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
      References
      ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
      Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
      Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
      FormLyophilized
      Hill FormulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
      Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKG1α
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      370677-1UMOLCN 04055977191707

      Documentation

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      370677

      References

      참고문헌 보기
      Abd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
      Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
      Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2008 RFH
      SynonymsRp-8-pCPT-cGMPS, TEA, PKG Inhibitor III
      DescriptionA potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg.
      FormLyophilized
      Chemical formulaC₁₆H₁₅ClN₅O₆PS₂ · C₆H₁₅N
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO or H₂O (0.5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAbd Alla, S., et al. 1996. Eur. J. Biochem. 241, 498.
      Lee, S.J., et al. 1996. Dev. Biol. 180, 324.
      Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
      Willmott, N., et al. 1996. J. Biol. Chem. 271, 3699.
      Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265.