수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

371724 Sigma-AldrichGPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem

The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist

Recommended Products

개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
330981-72-1	C₁₃H₁₄BrN₃O

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
371724-10MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Glass bottle	10 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A pyrimidine compound that acts as an effective GPR119 agonist (EC₅₀ = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.44 and 0.22, respectively, with or without 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (100 mg/kg; p.o.) without any significant hypoglycemic effect in vivo.
Catalogue Number	371724
Brand Family	Calbiochem®
Synonyms	2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist

References
References	Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.

Product Information
CAS number	330981-72-1
Form	Amber solid
Hill Formula	C₁₃H₁₄BrN₃O
Chemical formula	C₁₃H₁₄BrN₃O
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
371724-10MGCN	04055977213263

Documentation

GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem Certificates of Analysis

Title	Lot Number
371724	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-September-2012 JSW
Synonyms	2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist
Description	A pyrimidine compound that acts as an effective GPR119 agonist (EC₅₀ = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC_0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.
Form	Amber solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	330981-72-1
Chemical formula	C₁₃H₁₄BrN₃O
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (>10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Regulatory Review
References	Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.

카테고리

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > G-Protein Activators

해당 제품은 고객님의 카트에 추가되었습니다.