EphB1 Protein, active, 10 µg

51.4kDa

FUNCTION: SwissProt: P54762 # Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.
SIZE: 984 amino acids; 109885 Da
SUBUNIT: The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Preferentially expressed in brain.
SIMILARITY: SwissProt: P54762 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.

6 months at -70°C from date of shipment

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

routinely evaluated by phosphorylation of 250μM Src Substrate Peptide (Catalog # 12-140

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