수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

324683 Sigma-AldrichEllagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem

A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: 4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II

Primary Target: CDK2

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개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
476-66-4	C₁₄H₆O₈ · 2H₂O

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
324683-500MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Glass bottle	500 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A cell-permeable, reversible, potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC₅₀ = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC₅₀ = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC₅₀ >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
Catalogue Number	324683
Brand Family	Calbiochem®
Synonyms	4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II

References
References	Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

Product Information
CAS number	476-66-4
ATP Competitive	Y
Form	Slightly Beige Powder
Hill Formula	C₁₄H₆O₈ · 2H₂O
Chemical formula	C₁₄H₆O₈ · 2H₂O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CDK2
Primary Target IC<sub>50</sub>	40 nM against CK2; 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, against DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR, respectively
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	DJ2620000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+15°C to +30°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
324683-500MGCN	04055977196856

Documentation

Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem Certificates of Analysis

Title	Lot Number
324683	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-February-2019 JSW
Synonyms	4,4ʹ,5,5ʹ,6,6ʹ-Hexahydroxydiphenic Acid 2,6,2ʹ,6ʹ-Dilactone, TBBD, PRMT Inhibitor II
Description	A cell-permeable, reversible, and potent antioxidant that has anti-mutagenic and anti-carcinogenic properties. Acts as a selective and ATP-competitive inhibitor of CK2 (IC₅₀ = 40 nM). Moderately inhibits DNA topoisomerases I and II, Lyn, PKA catalytic subunit, Lyk, GSK-3, PKC, and FGR (IC₅₀ = 1.8, 2.1, 2.9, 3.5, 4.3, 7.5, 8.0, and 9.4 µM, respectively). Only minimally inhibits DYRK1a, CSK, RET, Flt3, and NPM-ALK (IC₅₀ >40 µM). Shown to act as an uncompetitive inhibitor of arginine methyltransferase CARM1 and block histone H3R17 methylation.
Form	Slightly Beige Powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	476-66-4
RTECS	DJ2620000
Chemical formula	C₁₄H₆O₈ · 2H₂O
Structure formula
Purity	≥98% by HPLC
Solubility	1 M NaOH (10 mg/ml) or Ethanol (10 mg/ml). For complete solubilization in ethanol, slight heating may be required.
Storage	Protect from light +15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 week at -20°C. Alkaline solutions are unstable and should be prepared just prior to use.
Toxicity	Irritant
Merck USA index	14, 3547
References	Selvi, B.R., et al. 2009, J. Biol. Chem. In press. Cozza, G., et al. 2006. J. Med. Chem. 49, 2363. Wang, B.H., et al. 1998. Planta Med. 64, 195. Constantinou, A., et al. 1995. Nutr. Cancer 23, 121. Hickey, M.J., et al. 1995. Biochem. Soc. Trans. 23, 607s.

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