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341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

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341207
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개요

주요 사양표

CAS #Empirical Formula
70641-51-9C₂₇H₅₈NO₆P

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341207-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
      Catalogue Number341207
      Brand Family Calbiochem®
      SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
      References
      ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
      Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
      Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
      Helfman, D., et al. 1993. Cancer Res. 53, 2955.
      Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
      Powis, G., et al. 1992. Cancer Res. 52, 2835.
      Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
      Product Information
      CAS number70641-51-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₇H₅₈NO₆P
      Chemical formulaC₂₇H₅₈NO₆P
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPI-PLC
      Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSYK0718000
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
      Global Trade Item Number
      카탈로그 번호 GTIN
      341207-5MGCN 04055977215441