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219477 Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 - Calbiochem

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219477
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주요 사양표

CAS #Empirical Formula
141992-47-4C₁₅H₁₃NO₂S

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219477-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC50 = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC50 > 100 µM).
      Catalogue Number219477
      Brand Family Calbiochem®
      Synonyms1,4-Dimethoxyacridine-9(10H)-thione
      References
      ReferencesKubo, A., et al. 1999. Clin. Cancer Res. 5, 4279.
      Product Information
      CAS number141992-47-4
      ATP CompetitiveN
      FormBrown solid
      Hill FormulaC₁₅H₁₃NO₂S
      Chemical formulaC₁₅H₁₃NO₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCDK4/D1
      Primary Target IC<sub>50</sub>200 nM against CDK4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      카탈로그 번호 GTIN
      219477-5MGCN 04055977218541