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219373 Cathepsin G, Human Neutrophil

Cathepsin G, Human Neutrophil, CAS 107200-92-0, is a purified native cathepsin G. Acts as a potent agonist of human platelet activation leading to their aggregation.

Cathepsin G, Human Neutrophil MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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219373
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개요

Replacement Information

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카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
219373-100MIUCN
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      		 Plastic ampoule 100 miu
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      Description
      OverviewNative cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Reported to be involved in the activation of pro MMP-2 via mechanism requiring MT1-MMP. Inhibited by chymostatin, DFP, and Z-Phe-CH2Br. Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5.
      Note: 1 mU = 1 milliunit.
      Catalogue Number219373
      Brand Family Calbiochem®
      References
      ReferencesGlusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
      Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
      Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
      Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
      Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
      Maison, C.M., et al. 1991. J. Immunol. 147, 921.
      Travis, J. 1988. Am. J. Med. 84, 37.
      Product Information
      CAS number107200-92-0
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-<i>p</i>NA per min at 25°C, pH 7.5.
      EC number3.4.21.20
      FormSalt-free lyophilized solid
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥2 units/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      219373-100MIUCN 04055977201574

      Documentation

      Cathepsin G, Human Neutrophil MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Cathepsin G, Human Neutrophil Certificates of Analysis

      TitleLot Number
      219373

      References

      참고문헌 보기
      Glusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
      Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
      Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
      Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
      Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
      Maison, C.M., et al. 1991. J. Immunol. 147, 921.
      Travis, J. 1988. Am. J. Med. 84, 37.

      Brochure

      Title
      Cathepsins and Related Products Technical Bulletin

      Citations

      타이틀
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionNative cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases, such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Inhibited by chymostatins, DFP and Z-Phe-CH2Br.
      FormSalt-free lyophilized solid
      SourcePrepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number107200-92-0
      EC number3.4.21.20
      Purity≥95% by SDS-PAGE
      Specific activity≥2 units/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-pNA per min at 25°C, pH 7.5.
      SolubilityReconstitute in 50 mM NaOAc and 150 mM NaCl, pH 5.5.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 6 months at -70°C.
      Toxicity Standard Handling
      Merck USA index14, 1905
      ReferencesGlusa, E., and Adam C. 2001. Por. J. Pharmacol. 133, 422.
      Shamamian, P., et al. 2001. J. Cell Physiol. 189, 197.
      Groutas, W.C., et al. 1993. Biochem. Biophys. Res. Commun. 197, 730.
      Stone, P.J., et al. 1993. Biochem. Biophys. Res. Commun. 197, 130.
      Groutas, W.C., et al. 1992. Arch. Biochem. Biophys. 294, 144.
      Maison, C.M., et al. 1991. J. Immunol. 147, 921.
      Travis, J. 1988. Am. J. Med. 84, 37.
      Citation
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    • Valerie A. Fadok, et al. (2001) Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases. Journal of Immunology 166, 6847-6854.
      		•