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400011 Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem

Caspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeability.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO

Primary Target: Caspase-1
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400011
가격 및 재고 조회

개요

Replacement Information

주요 사양표

Empirical Formula
C₉₇H₁₆₀N₂₀O₂₄

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
400011-1MGCN
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
      Catalogue Number400011
      Brand Family Calbiochem®
      SynonymsICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
      Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
      Thornberry, N.A., et al. 1992. Nature 356, 768.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉₇H₁₆₀N₂₀O₂₄
      Chemical formulaC₉₇H₁₆₀N₂₀O₂₄
      ReversibleY
      Quality LevelMQ100
      Applications
      ApplicationCaspase-1 Inhibitor I, Cell-Permeable, inhibits the activity of caspase-1 (Ki = 1 nM), 4 & 5. The N-terminal corresponds to the h-region of the signal peptide of K-FGF that confers cell-permeability.
      Biological Information
      Primary TargetCaspase-1
      Primary Target K<sub>i</sub>1 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      400011-1MGCN 04055977212624

      Documentation

      Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Caspase-1 Inhibitor I, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      400011

      References

      참고문헌 보기
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
      Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      SynonymsICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO
      DescriptionA cell-permeable inhibitor of caspase-1 (ICE; interleukin-1β converting enzyme). The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
      FormWhite solid
      Chemical formulaC₉₇H₁₆₀N₂₀O₂₄
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
      Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
      Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
      Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
      Thornberry, N.A., et al. 1992. Nature 356, 768.