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400010 Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049

Primary Target: caspase-1, human recombinant
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400010
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
143313-51-3C₂₃H₃₂N₄O₈

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
400010-1MGCN
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      		 Plastic ampoule 1 mg
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      400010-5MGCN
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      예상 출고 가능일 
      단종품
      제한된 수량 가능
      재고여부 확인
        Remaining: will advise
          Remaining: will advise
          추천사항
          고객 서비스로 문의
          Contact Customer Service

          		 Plastic ampoule 5 mg
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          가격을 검색할 수 없습니다
          Minimum Quantity needs to be mulitiple of
          Maximum Quantity is
          가격 문의 추가 정보
          ()이 할인됨
           
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          Description
          OverviewA potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
          Catalogue Number400010
          Brand Family Calbiochem®
          SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
          References
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Los, M., et al. 1995. Nature 375, 81.
          Walker, N.P.C., et al. 1994. Cell 78, 343.
          Wilson, K.P., et al. 1994. Nature 370, 270.
          Thornberry, N.A., et al. 1992. Nature 356, 768.
          Product Information
          CAS number143313-51-3
          ATP CompetitiveN
          FormWhite powder
          Hill FormulaC₂₃H₃₂N₄O₈
          Chemical formulaC₂₃H₃₂N₄O₈
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcaspase-1, human recombinant
          Primary Target K<sub>i</sub>200 pM for human recombinant caspase-1
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          카탈로그 번호 GTIN
          400010-1MGCN 04055977212600
          400010-5MGCN 04055977212617

          Documentation

          Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem Certificates of Analysis

          TitleLot Number
          400010

          References

          참고문헌 보기
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Los, M., et al. 1995. Nature 375, 81.
          Walker, N.P.C., et al. 1994. Cell 78, 343.
          Wilson, K.P., et al. 1994. Nature 370, 270.
          Thornberry, N.A., et al. 1992. Nature 356, 768.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-July-2014 JSW
          SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
          DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
          FormWhite powder
          CAS number143313-51-3
          Chemical formulaC₂₃H₃₂N₄O₈
          Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (5 mg/ml) or H₂O
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Los, M., et al. 1995. Nature 375, 81.
          Walker, N.P.C., et al. 1994. Cell 78, 343.
          Wilson, K.P., et al. 1994. Nature 370, 270.
          Thornberry, N.A., et al. 1992. Nature 356, 768.

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          카테고리

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors