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238100 CRM1 Inhibitor III - CAS 1178871-47-0 - Calbiochem

The CRM1 Inhibitor III controls the biological activity of CRM1. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III

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238100
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
1178871-47-0C₁₆H₁₂BrClN₂O₂

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카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
238100-10MGCN
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      		 Glass bottle 10 mg
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      Description
      OverviewA cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.
      Catalogue Number238100
      Brand Family Calbiochem®
      Synonyms(Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
      References
      ReferencesMonovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.
      Product Information
      CAS number1178871-47-0
      FormYellow powder
      Hill FormulaC₁₆H₁₂BrClN₂O₂
      Chemical formulaC₁₆H₁₂BrClN₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      238100-10MGCN 04055977217247

      Documentation

      CRM1 Inhibitor III - CAS 1178871-47-0 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      CRM1 Inhibitor III - CAS 1178871-47-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      238100

      References

      참고문헌 보기
      Monovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms(Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
      DescriptionA cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1178871-47-0
      Chemical formulaC₁₆H₁₂BrClN₂O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMonovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.