Millipore Sigma Vibrant Logo

05-776 Anti-ZAP-70 Antibody, clone 1E7.2

Anti-ZAP-70 Antibody, clone 1E7.2 is an antibody against ZAP-70 for use in IC, IP & WB.

Anti-ZAP-70 Antibody, clone 1E7.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Immunological Signaling Gene Symbol: ZAP70, ZAP-70, TZK, STD, SRK UniProt Number: P43403
View Products on Sigmaaldrich.com
05-776
200 µg  
가격 검색...
가격을 검색할 수 없습니다
Minimum Quantity needs to be mulitiple of
Maximum Quantity is
가격 문의 추가 정보
()이 할인됨
 
—
가격 문의
—
현재 재고 없음 현재 재고 없음
예상 출고 가능일 
단종품
제한된 수량 가능
재고여부 확인
    Remaining: will advise
      Remaining: will advise
      추천사항
      고객 서비스로 문의
      Contact Customer Service

      특별 제공

       

      고객 서비스로 문의

      개요

      Replacement Information

      특별 제공

      100% Performance Guaranteed

      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MICC, IP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-776
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-ZAP-70 Antibody, clone 1E7.2
      OverviewNote: This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California
      References
      Product Information
      FormatPurified
      Presentationof 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Quality LevelMQ100
      Applications
      ApplicationAnti-ZAP-70 Antibody, clone 1E7.2 is an antibody against ZAP-70 for use in IC, IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein between the second SH2 domain and precedes the kinase domain corresponding to residues 282-307 of human ZAP-70
      Clone1E7.2
      HostMouse
      SpecificityZap-70
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
      Gene Symbol
      • ZAP70
      • ZAP-70
      • TZK
      • STD
      • SRK
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation.
      SIZE: 619 amino acids; 69872 Da
      SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity).
      TISSUE SPECIFICITY: Expressed in T- and natural killer cells.
      DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z.
      PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
      DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains.
      Molecular WeightMr ~70kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Jurkat cells
      Sales RestrictionsDue to license agreement restrictions, this product cannot be purchased for resale.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      05-776 04053252624308

      Documentation

      Anti-ZAP-70 Antibody, clone 1E7.2 MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Anti-ZAP-70 Antibody, clone 1E7.2 Certificates of Analysis

      TitleLot Number
      Anti-ZAP-70, clone 1E7.2 - 26824 26824
      Anti-ZAP-70, clone 1E7.2 - 3190950 3190950
      Anti-ZAP-70, clone 1E7.2 - 3897311 3897311
      Anti-ZAP-70, clone 1E7.2 - DAM1739159 DAM1739159
      Anti-ZAP-70, clone 1E7.2 - JBC1363175 JBC1363175
      Anti-Zap-70, clone 1E7.2 (mouse monoclonal IgG1) - 2464566 2464566
      Anti-Zap-70, clone 1E7.2 (mouse monoclonal IgG1) - 2187218 2187218
      Anti-Zap-70, clone 1E7.2 (mouse monoclonal IgG1) - 2273888 2273888
      Anti-Zap-70, clone 1E7.2 -2521194 2521194

      References

      Reference overviewPub Med ID
      TCR signaling: another Abl-bodied kinase joins the cascade.
      Wange, Ronald L
      Curr. Biol., 14: R562-4 (2004)  2004

      요약 표시       		15268875 15268875

      관련 제품 및 어플리케이션

      Related Products

      카탈로그 번호 설명  
      05-253 Anti-ZAP-70 Antibody, clone 2F3.2 가격 및 재고 조회
      05-253MG Anti-ZAP-70 Antibody, clone 2F3.2 가격 및 재고 조회
      16-209 Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate 가격 및 재고 조회
      16-210 Anti-ZAP-70 Antibody, clone 2F3.2, FITC conjugate 가격 및 재고 조회

      Included Positive Control

      카탈로그 번호 설명  
      12-303 Jurkat Cell Lysate 가격 및 재고 조회

      카테고리

      Life Science Research > Antibodies and Assays > Primary Antibodies