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MABS1276 Anti-TRAP-1 Antibody, clone TR-1

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MABS1276
100 μg  
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      개요

      Replacement Information

      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P), IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1276
      DescriptionAnti-TRAP-1 Antibody, clone TR-1
      Alternate Names
      • Heat shock protein 75 kDa, mitochondrial
      • TRAP-1
      • HSP 75
      • TNFR-associated protein 1
      • Tumor necrosis factor type 1 receptor-associated protein
      • TRAP-1
      Background InformationHeat shock protein 75 kDa, mitochondrial (UniProt Q12931; also known as HSP 75, TNFR-associated protein 1, TRAP-1, Tumor necrosis factor type 1 receptor-associated protein) is encoded by the TRAP1 (also known as HSP75) gene (Gene ID 10131) in human. The mammalian HSP70 family consists of the mitochondrial HSP75 (TRAP-1), the endoplasmic HSP78, the cytoplasmic HSC70 (a.k.a. HSC73 and HSP73) and its inducible counterpart HSP72 (a.k.a. HSP70). TRAP-1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis. TRAP1-deficiency results in enhanced mitochondrial respiration and fatty acid oxidation, as well as increased cellular accumulation of tricarboxylic acid cycle intermediates, ATP, and reactive oxygen species species. TRAP-1-deficient cells display suppressed glucose metabolism and strikingly enhanced invasiveness, implicating a tumor suppressor role of TRAP-1.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TRAP-1 Antibody, clone TR-1 is an antibody against TRAP-1 for use in Western Blotting, Immunohistochemistry (Paraffin), Immunoprecipitation.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAP-1 in normal human bladder and human bladder cancer tissue.
      Western Blotting Analysis: A representative lot detected TRAP-1 primarily in the inner mitochondrial membrane (IMM) and mitochondrial matrix (Mx), but not the outer mitochondrial membrane (OMM) or the intermembrane space (IMS) of fractionated mitochondria preparations from HeLa cells (Yoshida, S., et al. (2013). Proc. Natl. Acad. Sci. U. S. A. 110(17):E1604-E1612).
      Biological Information
      ImmunogenRecombinant protein corresponding to human TRAP-1.
      CloneTR-1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRAP1
      • HSP75
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~75 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected TRAP-1 in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABS1276 04055977300147

      Documentation

      Anti-TRAP-1 Antibody, clone TR-1 MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Anti-TRAP-1 Antibody, clone TR-1 Certificates of Analysis

      TitleLot Number
      Anti-TRAP-1, clone TR-1 - 3389946 3389946
      Anti-TRAP-1, clone TR-1 -Q2630369 Q2630369

      References

      Reference overviewPub Med ID
      Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
      Yoshida, S; Tsutsumi, S; Muhlebach, G; Sourbier, C; Lee, MJ; Lee, S; Vartholomaiou, E; Tatokoro, M; Beebe, K; Miyajima, N; Mohney, RP; Chen, Y; Hasumi, H; Xu, W; Fukushima, H; Nakamura, K; Koga, F; Kihara, K; Trepel, J; Picard, D; Neckers, L
      Proceedings of the National Academy of Sciences of the United States of America  110  E1604-12  2013

      요약 표시
      23564345 23564345
      The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties.
      Felts, SJ; Owen, BA; Nguyen, P; Trepel, J; Donner, DB; Toft, DO
      The Journal of biological chemistry  275  3305-12  2000

      요약 표시
      10652318 10652318