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MABS1709 Anti-R-Spondin 2 Antibody, clone 14C7.1

Anti-R-Spondin 2, clone 14C7.1, Cat. No. MABS1709, is a mouse monoclonal antibody that specifically targets R-Spondin 2 (RSPO2) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-R-Spondin 2 Antibody, clone 14C7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: RSPO2, UNQ9384/PRO34209 UniProt Number: Q6UXX9
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MABS1709
100 μg  
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      개요

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      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1709
      DescriptionAnti-R-Spondin 2 Antibody, clone 14C7.1
      Alternate Names
      • Roof plate-specific spondin-2
      • hRspo2
      Background InformationR-spondin-2 (UniProt: Q6UXX9; also known as Roof plate-specific spondin-2, hRspo2) is encoded by the RSPO2 (also known as UNQ9384/PRO34209) gene (Gene ID: 340419) in human. R-spondin-2 is a secreted protein that acts as an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR receptors. Upon binding to LGR receptors (LGR4, LGR5 or LGR6) these receptors associate with phosphorylated LRP6 and frizzled receptors, which are activated by extracellular Wnt receptors. These events trigger the canonical Wnt signaling pathway to increase expression of target genes. R-spondin-2 also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling pathway by acting as an inhibitor of ZNRF3, an E3 ubiquitin-protein ligase that serves as an important regulator of the Wnt signaling pathway. In humans, R-Spondin 2 is expressed in organs of endodermal origin in adults, including intestine and lungs and is reported to downregulated in tumors involving these organs. In the embryonic mice it is abundantly expressed in the hippocampus and in developing bones.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-R-Spondin 2, clone 14C7.1, Cat. No. MABS1709, is a mouse monoclonal antibody that specifically targets R-Spondin 2 (RSPO2) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution of this antibody detected RSPO2 in human pancreas, human kidney, and human bone marrow tissue.
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corresponding to 74 amino acids from the C-terminal end of human R-Spondin 2.
      Clone14C7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 14C7.1 specifically detects human R-spondin-2. It targets an epitope within 74 amino acids from the C-terminal end.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RSPO2
      • UNQ9384/PRO34209
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~35 kDa observed; 28.31 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human recombinant R-spondin 2 protein.

      Western Blotting Analysis: 0.02 µg/mL of this antibody detected 0.05 µg of human recombinant R-spondin 2 protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABS1709 04054839201387