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MABT64 Anti-Nectin-4/PVRL4 Antibody, clone N4.61

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MABT64
100 µg  
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      개요

      Replacement Information

      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, ELISA, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT64
      DescriptionAnti-Nectin-4/PVRL4 Antibody, clone N4.61
      Alternate Names
      • poliovirus receptor-related 4
      • Ig superfamily receptor LNIR
      • nectin 4
      • poliovirus receptor-related protein 4
      • nectin-4
      • Nectin-4
      Background InformationNectin-4 is also known as poliovirus receptor-related protein 4 (PRR4 or PVRL4). Nectins are known for being the receptors for the herpes simplex virus. Nectin-4 is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectin-4 is connected with the actin cytoskeleton through afadin inside the cell. Nectin-4 is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-4 seems to adhere primarily to cells expressing nectin-1 and vice versa.
      References
      Product Information
      FormatPurified
      Control
      • Ductal carcinoma tissue
      PresentationPurified mouse monoclonal IgG1κ Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Nectin-4/PVRL4 Antibody, clone N4.61 is an antibody against Nectin-4/PVRL4 for use in IH, ELISA & IP.
      Key Applications
      • Immunohistochemistry
      • ELISA
      • Immunoprecipitation
      Application NotesELISA Anaysis: A previous lot was used by an independent laboratory in ELISA (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).

      Immunoprecipitation Anaysis: A previous lot was used by an independent laboratory in IP (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).
      Biological Information
      ImmunogenRecombinant protein corresponding to human Nectin-4.
      CloneN4.61.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPoliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001 [PubMed 11544254]).[supplied by OMIM].
      Gene Symbol
      • PVRL4
      • PRR4
      • LNIR
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.

      SUBUNIT STRUCTURE: Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Potential. Cell junction › adherens junction. Note: Colocalizes with MLLT4 at cadherin-based adherens junctions.

      Processed poliovirus receptor-related protein 4: Secreted. Note: The secreted form is found in breast tumor patients.

      TISSUE SPECIFICTY: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

      PTM: The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.

      SEQUENCE SIMILARITIES: Belongs to the nectin family.

      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight55 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in ductal carcinoma tissue.

      Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected Nectin-4/PVRL4 in ductal carcinoma tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABT64 04053252749285

      Documentation

      Anti-Nectin-4/PVRL4 Antibody, clone N4.61 MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Anti-Nectin-4/PVRL4 Antibody, clone N4.61 Certificates of Analysis

      TitleLot Number
      Anti-Nectin-4/PVRL4, clone N4.61 - 2385964 2385964
      Anti-Nectin-4/PVRL4, clone N4.61 - 2469394 2469394
      Anti-Nectin-4/PVRL4, clone N4.61 - 2063192 2063192
      Anti-Nectin-4/PVRL4, clone N4.61 - 2344736 2344736
      Anti-Nectin-4/PVRL4, clone N4.61 - 3191407 3191407
      Anti-Nectin-4/PVRL4, clone N4.61 - 3494046 3494046
      Anti-Nectin-4/PVRL4, clone N4.61 - 3596841 3596841
      Anti-Nectin-4/PVRL4, clone N4.61 - 3744860 3744860
      Anti-Nectin-4/PVRL4, clone N4.61 - 3866326 3866326
      Anti-Nectin-4/PVRL4, clone N4.61 - 3905478 3905478

      References

      Reference overviewPub Med ID
      Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17.
      Fabre-Lafay, S; Garrido-Urbani, S; Reymond, N; Gonçalves, A; Dubreuil, P; Lopez, M
      The Journal of biological chemistry  280  19543-50  2005

      요약 표시
      15784625 15784625
      Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction.
      Reymond, N; Fabre, S; Lecocq, E; Adelaïde, J; Dubreuil, P; Lopez, M
      The Journal of biological chemistry  276  43205-15  2001

      요약 표시
      11544254 11544254